In combination with metformin and rosiglitazone, JANUVIA provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo with metformin and rosiglitazone (Table 12) at Week 18. At Week 54, mean reduction in A1C was -1.0% for patients treated with JANUVIA and -0.3% for patients treated with placebo in an analysis based on the intent-to-treat population. Rescue therapy was used in 18% of patients treated with JANUVIA 100 mg and 40% of patients treated with placebo. There was no significant difference between JANUVIA and placebo in body weight change.

As is typical for trials of agents to treat type 2 diabetes, the mean reduction in A1C with JANUVIA appears to be related to the degree of A1C elevation at baseline. Overall, the 200 mg daily dose did not provide greater glycemic efficacy than the 100 mg daily dose. The effect of JANUVIA on lipid endpoints was similar to placebo.

Common side effects people have besides Narcotic abuse *:

However, as with all drugs , there are side effects and you should discuss with your doctor. To quickly treat hypoglycemia, eat or drink a fast-acting source of sugar such as fruit juice, crackers, or a non-diet soda that contains sugar. Different medical groups recommend different A1C levels, so it’s always best to ask your doctor what’s best for you. The American Diabetes Association recommends an A1C goal of less than 7% for most adults. In 2018, the American College of Physicians (ACP) released guidance suggesting that an A1C target goal should be between 7% and 8%. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

Need help navigating the ups and downs of blood sugar (A1C)?

Sitagliptin is not extensively bound to plasma proteins. Therefore, the liquor storage ideas propensity of sitagliptin to be involved in clinically meaningful drug-drug interactions mediated by plasma protein binding displacement is very low. Inform patients that bullous pemphigoid may occur with this class of drugs.

JANUVIA may help lower your blood sugar (A1C).

Angioedema has also been reported gas x and alcohol interaction with other DPP-4 inhibitors. Use caution in a patient with a history of angioedema with another DPP-4 inhibitor because it is unknown whether such patients will be predisposed to angioedema with JANUVIA. Assess renal function prior to initiation of JANUVIA and periodically thereafter. Our Januvia (sitagliptin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Eligible, privately insured patients may pay as little as $5 per prescription.

It is often used to diagnose as well as monitor type 2 diabetes. A1C is also called HbA1c or the glycated hemoglobin A1C test. Some people who take medicines called DPP-4 goodbye letter to alcohol inhibitors like JANUVIA, may develop joint pain that can be severe. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Before you take JANUVIA, tell your doctor about all of your medical conditions.

1. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur.
2. We study millions of patients and 5,000 more each day.
3. Tell your doctor about all your current medicines and any medicine you start or stop using.
4. Rescue glycemic therapy was used in 5% of patients treated with JANUVIA 100 mg and 14% of patients treated with placebo.
5. Review the full Januvia information here, and speak to your health care provider if you have questions or concerns.

How to use the study?

In combination with pioglitazone, JANUVIA provided significant improvements in A1C and FPG compared to placebo with pioglitazone (Table 10). Rescue therapy was used in 7% of patients treated with JANUVIA 100 mg and 14% of patients treated with placebo. These differences are not considered to be clinically meaningful. No adverse effect on fertility was observed at 125 mg/kg (approximately 12 times human exposure at the MRHD of 100 mg/day based on AUC comparisons). At higher doses, nondose-related increased resorptions in females were observed (approximately 25 and 100 times human exposure at the MRHD based on AUC comparison). Inform patients that allergic reactions have been reported during postmarketing use of JANUVIA.

Patients using short-acting insulins were excluded unless the short-acting insulin was administered as part of a pre-mixed insulin. After the run-in period, patients with inadequate glycemic control (A1C 7.5% to 11%) were randomized to the addition of either 100 mg of JANUVIA or placebo, administered once daily. Patients were on a stable dose of insulin prior to enrollment with no changes in insulin dose permitted during the run-in period. Patients who failed to meet specific glycemic goals during the double-blind treatment period were to have uptitration of the background insulin dose as rescue therapy. A total of 441 patients with type 2 diabetes participated in a 24-week, randomized, double-blind, placebo-controlled study designed to assess the efficacy of JANUVIA in combination with glimepiride, with or without metformin. Patients entered a run-in treatment period on glimepiride (≥4 mg per day) alone or glimepiride in combination with metformin HCl (≥1500 mg per day).

The apparent terminal t½ following a 100 mg oral dose of sitagliptin was approximately 12.4 hours and renal clearance was approximately 350 mL/min. During pregnancy Januvia should be used only when prescribed. Your doctor may change your diabetes treatment during pregnancy. Find out everything you need to know about weight loss drugs in our prescription weight loss drug guide. Before you start Januvia, tell your doctor if you have a history of pancreatitis, heart failure or heart disease, or kidney disease.